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Pharmacological bypass of NAD(+) salvage pathway protects neurons from chemotherapy-induced degeneration
Axon degeneration, a hallmark of chemotherapy-induced peripheral neuropathy (CIPN), is thought to be caused by a loss of the essential metabolite nicotinamide adenine dinucleotide (NAD(+)) via the prodegenerative protein SARM1. Some studies challenge this notion, however, and suggest that an aberran...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6196523/ https://ncbi.nlm.nih.gov/pubmed/30257945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809392115 |
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