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Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
Theories of general anesthesia have shifted in focus from bulk lipid effects to specific interactions with membrane proteins. Target receptors include several subtypes of pentameric ligand-gated ion channels; however, structures of physiologically relevant proteins in this family have yet to define...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6196478/ https://ncbi.nlm.nih.gov/pubmed/30275330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809650115 |
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