Functional Validation of Virtual Screening for Novel Agents with General Anesthetic Action at Ligand-Gated Ion Channels

GABA(A) receptors play a crucial role in the actions of general anesthetics. The recently published crystal structure of the general anesthetic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of GABA(A) receptors, provided an opportunity to explore struct...

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Main Authors: Heusser, Stephanie A., Howard, Rebecca J., Borghese, Cecilia M., Cullins, Madeline A., Broemstrup, Torben, Lee, Ui S., Lindahl, Erik, Carlsson, Jens, Harris, R. Adron
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807073/
https://ncbi.nlm.nih.gov/pubmed/23950219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087692
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