Carregant...
Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and inter-subunit sites
Pentameric ligand-gated ion channels (pLGICs) are similar in structure but either inhibited or potentiated by alcohols and anesthetics. This dual modulation has previously not been understood, but the determination of X-ray structures of prokaryotic GLIC provides an ideal model system. Here, we show...
Guardat en:
| Autors principals: | , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787718/ https://ncbi.nlm.nih.gov/pubmed/23891290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.018 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|