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Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and inter-subunit sites

Pentameric ligand-gated ion channels (pLGICs) are similar in structure but either inhibited or potentiated by alcohols and anesthetics. This dual modulation has previously not been understood, but the determination of X-ray structures of prokaryotic GLIC provides an ideal model system. Here, we show...

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Autors principals: Brömstrup, Torben, Howard, Rebecca J., Trudell, James R., Harris, R. Adron, Lindahl, Erik
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787718/
https://ncbi.nlm.nih.gov/pubmed/23891290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.018
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