Učitavanje...

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and inter-subunit sites

Pentameric ligand-gated ion channels (pLGICs) are similar in structure but either inhibited or potentiated by alcohols and anesthetics. This dual modulation has previously not been understood, but the determination of X-ray structures of prokaryotic GLIC provides an ideal model system. Here, we show...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Brömstrup, Torben, Howard, Rebecca J., Trudell, James R., Harris, R. Adron, Lindahl, Erik
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787718/
https://ncbi.nlm.nih.gov/pubmed/23891290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.018
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!