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Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and inter-subunit sites
Pentameric ligand-gated ion channels (pLGICs) are similar in structure but either inhibited or potentiated by alcohols and anesthetics. This dual modulation has previously not been understood, but the determination of X-ray structures of prokaryotic GLIC provides an ideal model system. Here, we show...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787718/ https://ncbi.nlm.nih.gov/pubmed/23891290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.018 |
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