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Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation

Cav3.2 T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral inflammation, Cav3.2 channels are upregulated due to an increased association with the deubiquitinase USP5. Disrupting these interactions i...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Gadotti, Vinicius M., Zamponi, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194615/
https://ncbi.nlm.nih.gov/pubmed/30340616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0405-4
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