Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain

BACKGROUND: Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase US...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Gadotti, Vinicius M, Caballero, Agustin Garcia, Berger, N Daniel, Gladding, Clare M, Chen, Lina, Pfeifer, Tom A, Zamponi, Gerald W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364099/
https://ncbi.nlm.nih.gov/pubmed/25889575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0011-8
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