Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain

BACKGROUND: Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase US...

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Bibliografische gegevens
Gepubliceerd in:Mol Pain
Hoofdauteurs: Gadotti, Vinicius M, Caballero, Agustin Garcia, Berger, N Daniel, Gladding, Clare M, Chen, Lina, Pfeifer, Tom A, Zamponi, Gerald W
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364099/
https://ncbi.nlm.nih.gov/pubmed/25889575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0011-8
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