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Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation

Cav3.2 T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral inflammation, Cav3.2 channels are upregulated due to an increased association with the deubiquitinase USP5. Disrupting these interactions i...

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Pubblicato in:Mol Brain
Autori principali: Gadotti, Vinicius M., Zamponi, Gerald W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194615/
https://ncbi.nlm.nih.gov/pubmed/30340616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-018-0405-4
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