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Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy

Application of paramagnetic solid-state NMR to amyloids is demonstrated, using Y145Stop human prion protein modified with nitroxide spin-label or EDTA-Cu(2+) tags as a model. By using sample preparation protocols based on seeding with pre-formed fibrils we show that paramagnetic protein analogs can...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Theint, Theint, Xia, Yongjie, Nadaud, Philippe S., Mukhopadhyay, Dwaipayan, Schwieters, Charles D., Surewicz, Krystyna, Surewicz, Witold K., Jaroniec, Christopher P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193843/
https://ncbi.nlm.nih.gov/pubmed/30295029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b06758
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