Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

Mutations at position K171 in the kinase activation loop of Inhibitor of κB kinase beta (IKKβ) occur in multiple myeloma, spleen marginal zone lymphoma and mantle cell lymphoma. Previously, we demonstrated that these result in constitutive kinase activation and stimulate Signal Transducer and Activa...

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Publicat a:PLoS One
Autors principals: Meyer, April N., Gallo, Leandro H., Ko, Juyeon, Cardenas, Guillermo, Nelson, Katelyn N., Siari, Asma, Campos, Alexandre R., Whisenant, Thomas C., Donoghue, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193727/
https://ncbi.nlm.nih.gov/pubmed/30335863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206014
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