Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

Mutations at position K171 in the kinase activation loop of Inhibitor of κB kinase beta (IKKβ) occur in multiple myeloma, spleen marginal zone lymphoma and mantle cell lymphoma. Previously, we demonstrated that these result in constitutive kinase activation and stimulate Signal Transducer and Activa...

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Publicado en:PLoS One
Main Authors: Meyer, April N., Gallo, Leandro H., Ko, Juyeon, Cardenas, Guillermo, Nelson, Katelyn N., Siari, Asma, Campos, Alexandre R., Whisenant, Thomas C., Donoghue, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193727/
https://ncbi.nlm.nih.gov/pubmed/30335863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206014
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