Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors

AIM OF STUDY: Chromosomal translocations such as t(10;12)(q26,q12) are associated with intrahepatic cholangiocarcinoma, a universally fatal category of liver cancer. This translocation creates the oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 joined to Periphilin 1. The aims of thi...

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Bibliografische gegevens
Gepubliceerd in:Transl Oncol
Hoofdauteurs: Li, Fangda, Meyer, April N., Peiris, Malalage N., Nelson, Katelyn N., Donoghue, Daniel J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press 2020
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Original article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451725/
https://ncbi.nlm.nih.gov/pubmed/32854034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100853
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