Molecular Imaging of Radiolabeled Bispecific T-cell Engager (89)Zr-AMG211 Targeting CEA-positive Tumors

BACKGROUND: AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor. AMG 211 was labeled with zirconium-89 ((89)Zr) or fluorescent dye to evaluate the tumor targeting properties. EXPERIMENTAL DESI...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Waaijer, Stijn J.H., Warnders, Frank J., Stienen, Sabine, Friedrich, Matthias, Sternjak, Alexander, Cheung, H. Kam, Terwisscha van Scheltinga, Anton G.T., Schröder, Carolien P., de Vries, Elisabeth G.E., Lub-de Hooge, Marjolijn N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193542/
https://ncbi.nlm.nih.gov/pubmed/29980531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0786
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