Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer (89)Zr-imgatuzumab

Preclinical positron emission tomography (PET) imaging revealed a mismatch between in vivo epidermal growth factor receptor (EGFR) expression and EGFR antibody tracer tumor uptake. Shed EGFR ectodomain (sEGFR), which is present in cancer patient sera, can potentially bind tracer and therefore influe...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Pool, Martin, Kol, Arjan, Lub-de Hooge, Marjolijn N., Gerdes, Christian A., de Jong, Steven, de Vries, Elisabeth G.E., Terwisscha van Scheltinga, Anton G.T.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356542/
https://ncbi.nlm.nih.gov/pubmed/27602494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11827
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