Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer (89)Zr-imgatuzumab

Preclinical positron emission tomography (PET) imaging revealed a mismatch between in vivo epidermal growth factor receptor (EGFR) expression and EGFR antibody tracer tumor uptake. Shed EGFR ectodomain (sEGFR), which is present in cancer patient sera, can potentially bind tracer and therefore influe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pool, Martin, Kol, Arjan, Lub-de Hooge, Marjolijn N., Gerdes, Christian A., de Jong, Steven, de Vries, Elisabeth G.E., Terwisscha van Scheltinga, Anton G.T.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356542/
https://ncbi.nlm.nih.gov/pubmed/27602494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11827
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