Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer (89)Zr-imgatuzumab

Preclinical positron emission tomography (PET) imaging revealed a mismatch between in vivo epidermal growth factor receptor (EGFR) expression and EGFR antibody tracer tumor uptake. Shed EGFR ectodomain (sEGFR), which is present in cancer patient sera, can potentially bind tracer and therefore influe...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Pool, Martin, Kol, Arjan, Lub-de Hooge, Marjolijn N., Gerdes, Christian A., de Jong, Steven, de Vries, Elisabeth G.E., Terwisscha van Scheltinga, Anton G.T.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356542/
https://ncbi.nlm.nih.gov/pubmed/27602494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11827
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