A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that contribute to metastasis. Solid tumors are characterized by an acidic extracellular medium. We intend to take advantage of this tumor feature to de...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Alves, Daiane S, Westerfield, Justin M, Shi, Xiaojun, Nguyen, Vanessa P, Stefanski, Katherine M, Booth, Kristen R, Kim, Soyeon, Morrell-Falvey, Jennifer, Wang, Bing-Cheng, Abel, Steven M, Smith, Adam W, Barrera, Francisco N
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Structural Biology and Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192698/
https://ncbi.nlm.nih.gov/pubmed/30222105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36645
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