A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that contribute to metastasis. Solid tumors are characterized by an acidic extracellular medium. We intend to take advantage of this tumor feature to de...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Alves, Daiane S, Westerfield, Justin M, Shi, Xiaojun, Nguyen, Vanessa P, Stefanski, Katherine M, Booth, Kristen R, Kim, Soyeon, Morrell-Falvey, Jennifer, Wang, Bing-Cheng, Abel, Steven M, Smith, Adam W, Barrera, Francisco N
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192698/
https://ncbi.nlm.nih.gov/pubmed/30222105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36645
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados