A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that contribute to metastasis. Solid tumors are characterized by an acidic extracellular medium. We intend to take advantage of this tumor feature to de...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Alves, Daiane S, Westerfield, Justin M, Shi, Xiaojun, Nguyen, Vanessa P, Stefanski, Katherine M, Booth, Kristen R, Kim, Soyeon, Morrell-Falvey, Jennifer, Wang, Bing-Cheng, Abel, Steven M, Smith, Adam W, Barrera, Francisco N
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2018
Aiheet:
Structural Biology and Molecular Biophysics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192698/
https://ncbi.nlm.nih.gov/pubmed/30222105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36645
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