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Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation
Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibo...
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| Publicado no: | J Pharm Anal |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Xi'an Jiaotong University
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6191964/ https://ncbi.nlm.nih.gov/pubmed/30345143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2017.09.002 |
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