Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1

The Fc (fragment crystallizable) is a common structural region in immunoglobulin gamma (IgG) proteins, IgG-based multi-specific platforms, and Fc-fusion platform technologies. Changes in conformational stability, protein-protein interactions, and aggregation of NS0-produced human Fc1 were quantified...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Wu, Haixia, Truncali, Kristopher, Ritchie, Julie, Kroe-Barrett, Rachel, Singh, Sanjaya, Robinson, Anne S, Roberts, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966490/
https://ncbi.nlm.nih.gov/pubmed/26267255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1079678
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