Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high target burden. However, the requirements for optima...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Yang, Danlin, Giragossian, Craig, Castellano, Steven, Lasaro, Marcio, Xiao, Haiguang, Saraf, Himanshu, Hess Kenny, Cynthia, Rybina, Irina, Huang, Zhong-Fu, Ahlberg, Jennifer, Bigwarfe, Tammy, Myzithras, Maria, Waltz, Erica, Roberts, Simon, Kroe-Barrett, Rachel, Singh, Sanjaya
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627591/
https://ncbi.nlm.nih.gov/pubmed/28786732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1359455
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