Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high target burden. However, the requirements for optima...

Full description

Saved in:
Bibliographic Details
Published in:MAbs
Main Authors: Yang, Danlin, Giragossian, Craig, Castellano, Steven, Lasaro, Marcio, Xiao, Haiguang, Saraf, Himanshu, Hess Kenny, Cynthia, Rybina, Irina, Huang, Zhong-Fu, Ahlberg, Jennifer, Bigwarfe, Tammy, Myzithras, Maria, Waltz, Erica, Roberts, Simon, Kroe-Barrett, Rachel, Singh, Sanjaya
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627591/
https://ncbi.nlm.nih.gov/pubmed/28786732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1359455
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items