Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

Antibodies with pH-dependent binding to both target antigens and neonatal Fc receptor (FcRn) provide an alternative tool to conventional neutralizing antibodies, particularly for therapies where reduction in antigen level is challenging due to high target burden. However, the requirements for optima...

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Veröffentlicht in:MAbs
Hauptverfasser: Yang, Danlin, Giragossian, Craig, Castellano, Steven, Lasaro, Marcio, Xiao, Haiguang, Saraf, Himanshu, Hess Kenny, Cynthia, Rybina, Irina, Huang, Zhong-Fu, Ahlberg, Jennifer, Bigwarfe, Tammy, Myzithras, Maria, Waltz, Erica, Roberts, Simon, Kroe-Barrett, Rachel, Singh, Sanjaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627591/
https://ncbi.nlm.nih.gov/pubmed/28786732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1359455
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