Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20‐dependent negative feedback loop

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations of PARK2 and PARK6, encoding the E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1...

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發表在:Glia
Main Authors: Mouton‐Liger, François, Rosazza, Thibault, Sepulveda‐Diaz, Julia, Ieang, Amélie, Hassoun, Sidi‐Mohamed, Claire, Emilie, Mangone, Graziella, Brice, Alexis, Michel, Patrick P., Corvol, Jean‐Christophe, Corti, Olga
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190839/
https://ncbi.nlm.nih.gov/pubmed/29665074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23337
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