Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain

Mutations in the gene for parkin, a 52-kDa E3 ubiquitin ligase, are a major cause of hereditary Parkinson's disease (PD). In vitro studies have identified a large number of parkin-interacting proteins. Whether parkin exists as a monomer or as part of a stable protein complex in vivo is uncertai...

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Bibliographic Details
Main Authors: Van Humbeeck, Cindy, Waelkens, Etienne, Corti, Olga, Brice, Alexis, Vandenberghe, Wim
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2008
Subjects:
Research Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253705/
https://ncbi.nlm.nih.gov/pubmed/18190519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2007.06000.x
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