Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20‐dependent negative feedback loop

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations of PARK2 and PARK6, encoding the E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1...

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Dettagli Bibliografici
Pubblicato in:Glia
Autori principali: Mouton‐Liger, François, Rosazza, Thibault, Sepulveda‐Diaz, Julia, Ieang, Amélie, Hassoun, Sidi‐Mohamed, Claire, Emilie, Mangone, Graziella, Brice, Alexis, Michel, Patrick P., Corvol, Jean‐Christophe, Corti, Olga
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190839/
https://ncbi.nlm.nih.gov/pubmed/29665074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23337
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