Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/ Nuclear factor (erythroid-derived 2)-like 2 (NRF2) Inhibitors

Activators of Nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription factor NRF2 is mediated by Kelch-like ECH-associated prote...

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Published in:J Med Chem
Main Authors: Richardson, Benjamin G., Jain, Atul D., Potteti, Haranatha, Lazzara, Phillip R., David, Brian P., Tamatam, Chandra, Choma, Ewelina, Skowron, Kornelia, Dye, Katherine, Siddiqui, Zamia, Wang, Yue-Ting, Krunic, Aleksej, Reddy, Sekhar P., Moore, Terry W.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190829/
https://ncbi.nlm.nih.gov/pubmed/30122040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01133
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