Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors

[Image: see text] The oxidative stress response, gated by the protein–protein interaction of KEAP1 and NRF2, has garnered significant interest in the past decade. Misregulation in this pathway has been implicated in disease states such as multiple sclerosis, rheumatoid arthritis, and diabetic chroni...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Lazzara, Phillip R., Jain, Atul D., Maldonado, Amanda C., Richardson, Benjamin, Skowron, Kornelia J., David, Brian P., Siddiqui, Zamia, Ratia, Kiira M., Moore, Terry W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153276/
https://ncbi.nlm.nih.gov/pubmed/32292559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00631
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