Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors

[Image: see text] The oxidative stress response, gated by the protein–protein interaction of KEAP1 and NRF2, has garnered significant interest in the past decade. Misregulation in this pathway has been implicated in disease states such as multiple sclerosis, rheumatoid arthritis, and diabetic chroni...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Lazzara, Phillip R., Jain, Atul D., Maldonado, Amanda C., Richardson, Benjamin, Skowron, Kornelia J., David, Brian P., Siddiqui, Zamia, Ratia, Kiira M., Moore, Terry W.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153276/
https://ncbi.nlm.nih.gov/pubmed/32292559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00631
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