CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum

We previously described a mechanism of acquired resistance of B-cell acute lymphoblastic leukemia to CD19-directed chimeric antigen receptor T-cell (CART) immunotherapy. It was based on in-frame insertions in or skipping of CD19 exon 2. To distinguish between epitope loss and defects in surface loca...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Bagashev, Asen, Sotillo, Elena, Tang, Chih-Hang Anthony, Black, Kathryn L., Perazzelli, Jessica, Seeholzer, Steven H., Argon, Yair, Barrett, David M., Grupp, Stephan A., Hu, Chih-Chi Andrew, Thomas-Tikhonenko, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189457/
https://ncbi.nlm.nih.gov/pubmed/30104252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00383-18
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