Ca(2+) binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection

The allosteric activation of the intrinsically disordered enzyme Staphylococcus aureus sortase A is initiated via binding of a Ca(2+) ion. Although Ca(2+) binding was shown to initiate structural changes inducing disorder-to-order transitions, the details of the allosteric activation mechanism remai...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Ugur, Ilke, Schatte, Martin, Marion, Antoine, Glaser, Manuel, Boenitz-Dulat, Mara, Antes, Iris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188747/
https://ncbi.nlm.nih.gov/pubmed/30321208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205057
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