Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca(2+) regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved th...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Guan, Ronghua, Zhou, Hui, Li, Junwei, Xiao, Shaoying, Pang, Chunli, Chen, Yafei, Du, Xiangrong, Ke, Shaoxi, Tang, Qiongyao, Su, Jiguo, Zhan, Yong, An, Hailong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://ncbi.nlm.nih.gov/pubmed/28953901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182067
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