Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca(2+) regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Guan, Ronghua, Zhou, Hui, Li, Junwei, Xiao, Shaoying, Pang, Chunli, Chen, Yafei, Du, Xiangrong, Ke, Shaoxi, Tang, Qiongyao, Su, Jiguo, Zhan, Yong, An, Hailong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://ncbi.nlm.nih.gov/pubmed/28953901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182067
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