Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca(2+) regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved th...

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Bibliographic Details
Published in:PLoS One
Main Authors: Guan, Ronghua, Zhou, Hui, Li, Junwei, Xiao, Shaoying, Pang, Chunli, Chen, Yafei, Du, Xiangrong, Ke, Shaoxi, Tang, Qiongyao, Su, Jiguo, Zhan, Yong, An, Hailong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://ncbi.nlm.nih.gov/pubmed/28953901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182067
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