Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca(2+) regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved th...

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Pubblicato in:PLoS One
Autori principali: Guan, Ronghua, Zhou, Hui, Li, Junwei, Xiao, Shaoying, Pang, Chunli, Chen, Yafei, Du, Xiangrong, Ke, Shaoxi, Tang, Qiongyao, Su, Jiguo, Zhan, Yong, An, Hailong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://ncbi.nlm.nih.gov/pubmed/28953901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182067
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