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Biophysical Inference of Epistasis and the Effects of Mutations on Protein Stability and Function
Understanding the relationship between protein sequence, function, and stability is a fundamental problem in biology. The essential function of many proteins that fold into a specific structure is their ability to bind to a ligand, which can be assayed for thousands of mutated variants. However, bin...
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| Publicat a: | Mol Biol Evol |
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| Autor principal: | |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6188545/ https://ncbi.nlm.nih.gov/pubmed/30085303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy141 |
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