Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin

If the fitness effects of amino acid mutations are conditional on genetic background, then mutations can have different effects depending on the sequential order in which they occur during evolutionary transitions in protein function. A key question concerns the fraction of possible mutational pathw...

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Gepubliceerd in:Mol Biol Evol
Hoofdauteurs: Kumar, Amit, Natarajan, Chandrasekhar, Moriyama, Hideaki, Witt, Christopher C., Weber, Roy E., Fago, Angela, Storz, Jay F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400398/
https://ncbi.nlm.nih.gov/pubmed/28201714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msx085
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