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Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin
If the fitness effects of amino acid mutations are conditional on genetic background, then mutations can have different effects depending on the sequential order in which they occur during evolutionary transitions in protein function. A key question concerns the fraction of possible mutational pathw...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Biol Evol |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5400398/ https://ncbi.nlm.nih.gov/pubmed/28201714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msx085 |
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