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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in de...

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Veröffentlicht in:Science
Hauptverfasser: Natarajan, Chandrasekhar, Inoguchi, Noriko, Weber, Roy E., Fago, Angela, Moriyama, Hideaki, Storz, Jay F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409680/
https://ncbi.nlm.nih.gov/pubmed/23766324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236862
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