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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin
Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in de...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Science |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4409680/ https://ncbi.nlm.nih.gov/pubmed/23766324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236862 |
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