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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin
Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in de...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4409680/ https://ncbi.nlm.nih.gov/pubmed/23766324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1236862 |
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