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Compensatory mutations and epistasis for protein function

Adaptive protein evolution may be facilitated by neutral amino acid mutations that confer no benefit when they first arise but which potentiate subsequent function-altering mutations via direct or indirect structural mechanisms. Theoretical and empirical results indicate that such compensatory inter...

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Bibliografiske detaljer
Udgivet i:Curr Opin Struct Biol
Hovedforfatter: Storz, Jay F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936477/
https://ncbi.nlm.nih.gov/pubmed/29100081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2017.10.009
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