The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease

The central pathological feature of Alzheimer's disease (AD) is the sequential proteolytic processing of amyloid precursor protein (APP) to amyloid-β peptides (Aβ) agglomeration. The clearance of Aβ may be induced by the large zinc-binding protease insulin degrading enzyme (IDE). IDE is the com...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Hayrabedyan, Soren, Todorova, Krassimira, Spinelli, Marialuigia, Barnea, Eytan R., Mueller, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188057/
https://ncbi.nlm.nih.gov/pubmed/30338033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26057
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