Insight into PreImplantation Factor (PIF*) Mechanism for Embryo Protection and Development: Target Oxidative Stress and Protein Misfolding (PDI and HSP) through Essential RIPK Binding Site

BACKGROUND: Endogenous PIF, upon which embryo development is dependent, is secreted only by viable mammalian embryos, and absent in non-viable ones. Synthetic PIF (sPIF) administration promotes singly cultured embryos development and protects against their demise caused by embryo-toxic serum. To ide...

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Main Authors: Barnea, Eytan R., Lubman, David M., Liu, Yan-Hui, Absalon-Medina, Victor, Hayrabedyan, Soren, Todorova, Krassimira, Gilbert, Robert O., Guingab, Joy, Barder, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077574/
https://ncbi.nlm.nih.gov/pubmed/24983882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100263
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