Discovery of Novel 4-Arylisochromenes as Anticancer Agents Inhibiting Tubulin Polymerization

[Image: see text] XJP-L (8), a derivative of the natural product (±)-7,8-dihydroxy-3-methylisochroman-4-one isolated from the peel of Musa sapien tum L., was found to exhibit weak inhibitory activity of tubulin polymerization (IC(50) = 10.6 μM) in our previous studies. Thus, a series of 4-arylisochr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Li, Wenlong, Shuai, Wen, Xu, Feijie, Sun, Honghao, Xu, Shengtao, Yao, Hong, Liu, Jie, Yao, Hequan, Zhu, Zheying, Xu, Jinyi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2018
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187416/
https://ncbi.nlm.nih.gov/pubmed/30344902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00217
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