Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides

[Image: see text] A novel series of of 4-[(3-phenyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides (EMAC10111a–g) was synthesized and assayed toward both human carbonic anhydrase isozymes I, II, IX, and XII and cyclooxygenase isoforms. The majority of these derivatives prefere...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Meleddu, Rita, Distinto, Simona, Cottiglia, Filippo, Angius, Rossella, Gaspari, Marco, Taverna, Domenico, Melis, Claudia, Angeli, Andrea, Bianco, Giulia, Deplano, Serenella, Fois, Benedetta, Del Prete, Sonia, Capasso, Clemente, Alcaro, Stefano, Ortuso, Francesco, Yanez, Matilde, Supuran, Claudiu T., Maccioni, Elias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187410/
https://ncbi.nlm.nih.gov/pubmed/30344915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00352
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