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Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors

Sorafenib, a multikinase inhibitor with antiproliferative, antiangiogenic, and proapoptotic properties, constitutes the only effective first-line drug approved for the treatment of advanced hepatocellular carcinoma (HCC). Despite its capacity to increase survival in HCC patients, its success is quit...

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Détails bibliographiques
Publié dans:Exp Mol Med
Auteurs principaux: Méndez-Blanco, Carolina, Fondevila, Flavia, García-Palomo, Andrés, González-Gallego, Javier, Mauriz, José L.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185986/
https://ncbi.nlm.nih.gov/pubmed/30315182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0159-1
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