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Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers

Regorafenib is a sorafenib-derived chemotherapy drug belonging to the multikinase inhibitor family. This agent effectively targets a wide range of tyrosine kinases involved in cancer biology, such as those implicated in oncogenesis, angiogenesis, and tumor microenvironment control. The beneficial ef...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Fondevila, Flavia, Méndez-Blanco, Carolina, Fernández-Palanca, Paula, González-Gallego, Javier, Mauriz, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802659/
https://ncbi.nlm.nih.gov/pubmed/31551425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0308-1
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