Stabilization of Hypoxia-Inducible Factors and BNIP3 Promoter Methylation Contribute to Acquired Sorafenib Resistance in Human Hepatocarcinoma Cells

Despite sorafenib effectiveness against advanced hepatocarcinoma (HCC), long-term exposure to antiangiogenic drugs leads to hypoxic microenvironment, a key contributor to chemoresistance acquisition. We aimed to study the role of hypoxia in the development of sorafenib resistance in a human HCC in v...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Méndez-Blanco, Carolina, Fondevila, Flavia, Fernández-Palanca, Paula, García-Palomo, Andrés, van Pelt, Jos, Verslype, Chris, González-Gallego, Javier, Mauriz, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966438/
https://ncbi.nlm.nih.gov/pubmed/31835431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121984
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