A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN

PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P(2) and PI(3,4,5)P(3). The structural determinants of this important specificity remain unknown. Interestingly, PTEN shares remarkable homology to voltage-sensitive phosphatases...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Leitner, Michael G., Hobiger, Kirstin, Mavrantoni, Angeliki, Feuer, Anja, Oberwinkler, Johannes, Oliver, Dominik, Halaszovich, Christian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182344/
https://ncbi.nlm.nih.gov/pubmed/29987362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-018-2867-z
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