Discovery and functional characterization of a neomorphic PTEN mutation

Although a variety of genetic alterations have been found across cancer types, the identification and functional characterization of candidate driver genetic lesions in an individual patient and their translation into clinically actionable strategies remain major hurdles. Here, we use whole genome s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Costa, Helio A., Leitner, Michael G., Sos, Martin L., Mavrantoni, Angeliki, Rychkova, Anna, Johnson, Jeffrey R., Newton, Billy W., Yee, Muh-Ching, De La Vega, Francisco M., Ford, James M., Krogan, Nevan J., Shokat, Kevan M., Oliver, Dominik, Halaszovich, Christian R., Bustamante, Carlos D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653168/
https://ncbi.nlm.nih.gov/pubmed/26504226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422504112
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