SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis

Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished tumor-incidence and metastasis. In breast cancer, TGF-β-mediated induction of SOX4 ha...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Vervoort, Stephin J, Lourenço, Ana Rita, Tufegdzic Vidakovic, Ana, Mocholi, Enric, Sandoval, José L, Rueda, Oscar M, Frederiks, Cynthia, Pals, Cornelieke, Peeters, Janneke G C, Caldas, Carlos, Bruna, Alejandra, Coffer, Paul J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182182/
https://ncbi.nlm.nih.gov/pubmed/30137431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky755
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