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Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome
The transforming growth factor beta (TGF-β) signaling pathway exerts opposing effects on cancer cells, acting as either a tumor promoter or a tumor suppressor. Here, we show that these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGF-β signaling, and the disti...
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Veröffentlicht in: | Cell Rep |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Cell Press
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4695334/ https://ncbi.nlm.nih.gov/pubmed/26686634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.040 |
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