Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome

The transforming growth factor beta (TGF-β) signaling pathway exerts opposing effects on cancer cells, acting as either a tumor promoter or a tumor suppressor. Here, we show that these opposing effects are a result of the synergy between SMAD3, a downstream effector of TGF-β signaling, and the disti...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tufegdzic Vidakovic, Ana, Rueda, Oscar M., Vervoort, Stephin J., Sati Batra, Ankita, Goldgraben, Mae Akilina, Uribe-Lewis, Santiago, Greenwood, Wendy, Coffer, Paul J., Bruna, Alejandra, Caldas, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695334/
https://ncbi.nlm.nih.gov/pubmed/26686634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.040
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