Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral edema and outcome in severe traumatic brain injury

OBJECTIVE: ABCC8 encodes sulfonylurea-receptor-1, a key regulatory protein of cerebral edema in many neurological disorders including traumatic brain injury (TBI). Sulfonylurea-receptor-1 inhibition has been promising in ameliorating cerebral edema in clinical trials. We evaluated whether ABCC8 tag-...

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Publicado no:J Neurol Neurosurg Psychiatry
Main Authors: Jha, Ruchira M., Koleck, Theresa A., Puccio, Ava M., Okonkwo, David O., Park, Seo-Young, Zusman, Benjamin E., Clark, Robert S.B., Shutter, Lori A., Wallisch, Jessica S., Empey, Philip E., Kochanek, Patrick M., Conley, Yvette P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181785/
https://ncbi.nlm.nih.gov/pubmed/29674479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2017-317741
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