Lactobacillus plantarum prevents and mitigates alcohol-induced disruption of colonic epithelial tight junctions, endotoxemia, and liver damage by an EGF receptor–dependent mechanism

Pathogenesis of alcohol-related diseases such as alcoholic hepatitis involves gut barrier dysfunction, endotoxemia, and toxin-mediated cellular injury. Here we show that Lactobacillus plantarum not only blocks but also mitigates ethanol (EtOH)-induced gut and liver damage in mice. L. plantarum block...

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Udgivet i:FASEB J
Main Authors: Shukla, Pradeep K., Meena, Avtar S., Manda, Bhargavi, Gomes-Solecki, Maria, Dietrich, Paula, Dragatsis, Ioannis, Rao, RadhaKrishna
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181630/
https://ncbi.nlm.nih.gov/pubmed/29912589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800351R
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